We develop the science of pandemic prevention through transdisciplinary leadership, innovation, and translation. We bridge the best available science in disease dynamics with effective public health practice and meaningful policy. Our research focuses on six areas of inquiry: (1) transmission of pathogens between species, (2) links between land use change and pathogen spillover, (3) dynamics and drivers of viral pathogens in reservoir host populations, (4) prevention of pandemics, (5) post-emergence dynamics of pathogens in wildlife and (6) implementation of science for protection of ecosystem and human health.